Monosubstituted alkenyl amino acids for peptide "stapling".
نویسندگان
چکیده
Alkenylglycine amino acids were assessed as potential candidates for hydrocarbon stapling and shown to be effective in stapling of the BID BH3 peptide.
منابع مشابه
Robust asymmetric synthesis of unnatural alkenyl amino acids for conformationally constrained α-helix peptides.
The efficient asymmetric synthesis of unnatural alkenyl amino acids required for peptide 'stapling' has been achieved using alkylation of a fluorine-modified Ni(II) Schiff base complex as the key step.
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 80 شماره
صفحات -
تاریخ انتشار 2013